Masaaki Yamamoto, M.D., Ph.D.                                                                                   Home Page (Yamamoto)

• Title and Affiliation: 　Sakura　Doori　Clinic 　Chief　Doctor
• Former Associate Professor, Department of Neurosurgery, Fukuoka University School of Medicine
• Sex: Male
• Office Address: Department of Neurosurgery,
• Licensures/Boards: M.D. and Ph.D., Japanese Board of Neurological Surgery
  
  Education:

1984 - Fukuoka University School of Medicine, M.D. 
1990 - Fukuoka University Postgraduate School of Medical Science, Ph.D.

Academic and Professional Appointments:

6/1984 -3/1991 Neurosurgical residency and clinical fellowship, Department of Neurosurgery, Fukuoka University 
                       Hospital, Fukuoka, Japan.
4/1991 - 6/1993 Assistant Professor, Department of Neurosurgery, Fukuoka University School of Medicine, Fukuoka, 
                        Japan.
7/1993 -8/1995 Research fellow, Department of Neurosurgery, The University of Texas M. D. Anderson Cancer 
                       Center, Houston, Texas USA.
10/1995 -present Associate Professor, Department of Neurosurgery, Fukuoka University School of Medicine, 
                        Fukuoka, Japan.

Borad: 1990 - The Japanese Board of Neurological Surgery.

Clinical and Research Intrests

      
Headache

      
Brain tumor

      
Cerebrovascular Disease

      
Functional Neurological 
Disease

Headache

Brain Tumor
representative publications

• Expression and cellular localization of messenger RNA for plasminogen activator inhibitor type 1 in human astrocytomas in vivo /
  Yamamoto, M., Sawaya,R., Mohanam, S., Loskutoff, D.J., Bruner, J.M., Rao, V.H., Oka, K., Tomonaga, M., Nicolson, G.L., Rao,J.S. - Cancer Res. (1994, 54: 3329-3332)
• Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo /
  Yamamoto M., Sawaya, R., Mohanam, S., Bindyl, A.K., Bruner, J.M. Oka, K., Rao, V.H., Tomonaga, M., Nicolson, G.L., Rao,J.S. - Cancer Res.(1994, 54: 3656-3661)
• Expression and localization of urokinase-type plasminogen activator receptor in human gliomas /
  Yamamoto, M., Sawaya, R., Mohanam, S., Rao, V.H., Bruner, J.M., Nicolson, G.L., Rao, J.S. - Cancer Res.(1994, 54: 5016-5020)
• Activities, localizations, and roles of serine proteases and their inhibitors in human brain tumor progression /
  Yamamoto, M., Sawaya, R., Mohanam, S. Bruner, J.M., Nicolson, G.L., Ohshima, K., Rao,J.S. - J. Neuro-Oncology (1994, 22: 139-152)
• Plasminogen activator inhibitor-1 in brain tumors: Relation to malignancy and necrosis /
  Sawaya, S., Yamamoto, M., Ramo, O.J., Shi, M.L., Rao, J.S. - Neurosurgery (1995, 36(2): 375-381)
• Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro /
  Yamamoto, M., Mohanam, S., Sawaya, R., Fuller, G.N., Seiki, M., Sato, H., Gokaslan, Z.L., Liotta, L.A., Rao, J.S. - Cancer Res. (1996, 56: 384-392)
• Increased expression of low density lipoprotein receptor-related protein / a2-macroglobulin receptor in human malignant astrocytomas /
  Yamamoto, M., Ikeda, K., Ohshima, K., Tsugu, H., Kimura, H., Tomonaga, M. - Cancer Res.(1997, 57: 2799-2805)
• Fibrinolytic system in human brain tumors. In: Advances in Neuro-Oncology II (Kornblith, Paul L., Ed.) Futura Publishing Company, Inc., Armonk, NY, pp 49-68, 1997
  Rao, JS., Yamamoto, M., Bindal, AK., Shi, WM., Wu, SZ., and Sawaya, R.
• Giant cell tumor of the sphenoid bone: Long-term follow-up of two cases after chemotherapy /
  Yamamoto, M., Fukushima, T., Sakamoto, S., Tomonaga, M. - Surg. Neurol. (1998, 49: 547-552)
• Treatment of malignant astrocytomas with recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2) / Fukushima,T., Yamamoto, M., Ikeda, K., Tsugu, H., Kimura, H., Soma, G-I., Tomonaga, M. - Anticancer Research (1998, 18: 3965-3970)
• Correlation of the expression of nuclear factor-kB, tumor necrosis factor receptor type 1 (TNFR1) and c-Myc with the clinical course in the treatment of malignant astrocytomas with recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2)/
  Yamamoto, M., Fukushima, T., Hayashi, S., Ikeda, K., Tsugu, H., Kimura, H., Soma, G-I., Tomonaga, M.-Anticancer Res. (2000, 20:611-618)
• Clinical Significance of the Expression of Endothelial-Monocyte Activating Polypeptide II (EMAPII) in the Treatment of Glioblastoma with Recombinant Mutant Human Tumor Necrosis Factor-alpha (TNF-SAM2) /
  Yamamoto, M., FUKUSHIMA, F., UENO, Y., HAYASHI, S., KIMURA, H., SOMA, G., TOMONAGA, M.-Anticancer Res. (2000, 20,4081-4086)
• Expression of nuclear factor-kB, tumor necrosis factor receptor type 1, and c-Myc in human astrocytomas/
  Hayashi S., Yamamoto, M., Ueno, U., Ikeda, K., Ohshima, K., Soma G-I., Fukushima, T.- Neurologia Medico-Chirurgica (Tokyo) (2001, 41:185-193)

Cerebrovascular Disease

• Fructose 2, 6-bisphosphate on human erythrocyte /
  Moriyasu, M., Yamamoto, M., Hamasaki, N. - J. Biochem. (Tokyo) (1988, 103 (6): 903-904)
• Fructose 2, 6-bisphosphate changes in rat brain during ischemia /
  Yamamoto, M., Hamasaki, N., Maruta, Y., Tomonaga, M. - J. Neurochem. (1990, 54: 592-597)
• Circulation of red blood cells having high levels of 2, 3-Bisphosphoglycerate protects rat brain from ischemic metabolic changes during hemodilution /
  Kimura, H., Hamasaki, N., Yamamoto, M., Tomonaga, M. - Stroke (1995, 26: 1431-1437)
• The clinical significance of cerebral veins in Moyamoya disease /
  Kimura,H., Oka, K., Ikeda, K., Yamamoto, M., Tomonaga, M. - Clinical Neurology and Neurosurgery (1997, 99:S90-95)
• Red blood cell function and blood storage /
  Hamasaki, N. and Yamamoto, M. -Vox Sanguinis, (2000, 79:191-197)
• Expression of nucelar factor-kB and TNF-a in mouse brain following experimental thermal ablation injury /
  Nomoto, Y., Yamamoto, M., Fukushima, T., Kimura, H., Ohshima, K., Tomonaga, M. - Neurosurgery, (2001, 48: 158-166)

Functional Neurological Disease and Others

• Symptomatic Chiari malformation and associated pathophysiology in pediatric and adult patients without myelodysplasia /
  Fukushima, T., Matsuda, T., Tsuchimochi, H., Yamamoto, M., Tsugu, H., Tomonaga, M., Mitsudome,A., Utsunomiya, H., Asakawa, K. - Neurologia Medico-Chirurgica (Tokyo) (1994, 34(11):739-743)
• Percutaneous flexible neuroendoscopic ventriculostomy in patients with shunt malfunction as an alternative procedure to shunt revision /
  Yamamoto, M., Oka, K., Ikeda, K., Tomonaga, M. - Surgical Neurology (1994, 42: 218-223)
• Ventriculoscope-guided ventriculoperitoneal shunt and shunt revision - Technical note - /
  Yamamoto, M., Oka, K., Nagasaka, S., Tomonaga,M. - Acta Neurochirugica (Wien) (1994, 129: 85-88)
• Flexible Neuroendoscopy for percutaneous treatment of intraventricular lesions in the absence of hydrocephalus / Yamamoto, M., Oka, K., Hachisuka, S., Miyake, E., Tomonaga, M. - Minim. Invas. Neurosurg. (1997, 40(4): 139-143)

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